Gut and Joint Microbiomes: Implications in Osteoarthritis
Honey Hendesi1, David A Villani1, Janne Prawitt2
1Department of Orthopedics, University of Colorado, Anschutz Medical Campus, 12800 East 19th Avenue, RC1N, MS8343, Aurora, CO 80045, USA.
Rheumatic Diseases Clinics of North America
|April 17, 2025
Summary
Recent findings indicate that microbiomes, particularly the gut microbiome, may influence osteoarthritis development and progression. Targeting the gut microbiome presents a potential therapeutic avenue for managing this joint disease.
Area of Science:
- Microbiology
- Immunology
- Orthopedics
Background:
- Osteoarthritis (OA) is a prevalent degenerative joint disease.
- The role of the microbiome in OA pathogenesis is an emerging area of research.
Purpose of the Study:
- To review recent evidence linking microbiomes to osteoarthritis.
- To explore the gut-joint axis in OA and potential therapeutic strategies.
- To summarize data on the presence of a microbiome within synovial joints.
Main Methods:
- Literature review of human and animal studies.
- Analysis of microbial and molecular mechanisms.
- Evaluation of clinical data.
Main Results:
- Growing evidence supports a gut microbiome-joint connection in OA.
- Microbial and molecular factors in the gut may drive OA development.
- The presence of a microbiome within diarthrodial joints is supported by clinical data.
Conclusions:
- The microbiome, especially the gut microbiome, is implicated in osteoarthritis.
- Targeting the gut microbiome offers a promising therapeutic strategy for OA.
- Further research is needed to confirm the existence and role of synovial joint microbiomes.
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