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Animal Models Informing the Role of the Microbiome and its Metabolites in Rheumatoid Arthritis
Jing Li1, Jing He2, Kristine A Kuhn3
1Department of Rheumatology and Immunology, Peking University People's Hospital, No. 11, South Xizhimen Street, Xicheng District, Beijing, 100044, China; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), No. 11, South Xizhimen Street, Xicheng District, Beijing, 100044, China; Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, 13001 E 17th Place, Aurora, CO 80045, USA.
None:
Animal models of rheumatoid arthritis (RA) are essential for understanding the disease's mechanisms and developing new treatments. Recent research highlights the microbiome's significant roles in RA pathogenesis, influencing disease susceptibility and progression. These models allow researchers to investigate the causal relationships between specific microbial species and arthritis development. Despite challenges in translating findings to human conditions, animal models are crucial for uncovering microbiome-related therapeutic strategies, advancing our understanding of RA, and improving patient outcomes.
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