[Hemorrheological changes in microcirculation caused by fats of different dosage, composition and mode...

Descriptions of the nature and pathogenesis of disturbances of the microcirculation induced by intravenous infusion of a triglyceride emulsion or by daily oral administration of a cholesterol-in-oil suspension are different and partially contradictory in the medical literature. Hyperlipemic disturbances of the microcirculation are characterized by a general decrease in the rate of flow reflected in all parameters of flow in the terminal blood vessels including a rise of the number of capillaries temporarily functionally isolated from the circulation and by an increase in capillary plasma skimming. The degree is dependent upon the amount of administered fat and on lipid levels. The disturbed capillary perfusion can be attributed to various rheological mechanisms. The hemodynamical relevance of the short-time hyperlipemia produced by intravenous infusion of a fat emulsion and the enduring hyperlipemia produced by the daily oral administration of a cholesterol-in-oil suspension differ. Some of the capillary-rheological bases of these differences are discussed.