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Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
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Emerging Therapeutic Targets in Rheumatoid Arthritis: Focusing on HIF-1α, Nrf2, STATs, and RORγt

Pradyuman Prajapati1, Pankaj Singh1, Gaurav Doshi1

  • 1Department of Pharmacology, Toxicology and Therapeutics, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, V.M. Road, Vile Parle (W), Mumbai, India.

Current Drug Targets
|April 18, 2025
PubMed

Insights

Novel treatments for rheumatoid arthritis (RA) focus on targeting key transcription factors (TFs). This review explores natural compounds and synthetic drugs for safer and more effective RA therapies.

Area of Science:

  • Immunology
  • Pharmacology
  • Molecular Biology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease causing joint inflammation and damage.
  • Current RA treatments can lead to disease recurrence and adverse effects.
  • Novel therapeutic strategies are needed to improve RA management.

Purpose of the Study:

  • To review natural compounds and synthetic drugs targeting specific transcription factors (TFs) for rheumatoid arthritis (RA).
  • To highlight the role of TFs in RA pathogenesis and their potential as therapeutic targets.
  • To assess the current status of TF-targeting agents in RA treatment.

Main Methods:

  • Literature review of studies on transcription factors and RA.
  • Analysis of natural compounds and synthetic drugs targeting key TFs.
  • Focus on hypoxia-inducible factor 1α, nuclear factor erythroid 2-related factor 2, retinoic acid-related orphan receptor gamma t, and signal transducer and activator of transcription.

Main Results:

  • Transcription factors play a critical role in RA by regulating pro-inflammatory mediators.
  • Several natural compounds and synthetic drugs show potential for targeting these TFs.
  • These agents aim to offer more effective and safer alternatives to existing RA therapies.

Conclusions:

  • Targeting specific transcription factors represents a promising new avenue for RA treatment.
  • Further research into natural compounds and synthetic drugs is crucial for developing improved RA therapies.
  • This approach could lead to more personalized and effective management of rheumatoid arthritis.
Keywords:
Transcription factorsactivatorcytokineshypoxia-inducible factor 1αnovel approachnuclear factor erythroid 2-related factor 2retinoic acid-related orphan receptorrheumatoid arthritissignal transducertranscription.

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