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Combination therapy with oncolytic viruses for lung cancer treatment

Lei Sun1, Qi Zhao2, Liyun Miao1,2

  • 1Department of Pharmacy, Yancheng Branch of Nanjing Drum Tower Hospital, Yancheng, Jiangsu, China.

Frontiers in Oncology
|April 18, 2025
PubMed

Insights

Oncolytic viruses (OVs) show promise for lung cancer treatment. Combining OVs with other therapies, like immune checkpoint inhibitors, enhances anti-tumor effects, offering new hope for patients.

Area of Science:

  • Oncology
  • Virology
  • Immunotherapy

Background:

  • Lung cancer remains a leading cause of cancer mortality worldwide.
  • Existing treatments face limitations due to adverse reactions and resistance.
  • Novel therapeutic strategies are crucial for improving patient outcomes.

Purpose of the Study:

  • To review the current status and future prospects of oncolytic virus (OV) combination therapy for lung cancer.
  • To summarize the mechanisms of action for OV-based combination treatments.
  • To highlight the potential of OVs in overcoming treatment resistance in lung cancer.

Main Methods:

  • Review of existing literature on oncolytic virus therapy in lung cancer.
  • Analysis of preclinical and clinical studies investigating OV combination strategies.
  • Summary of proposed mechanisms for synergistic effects between OVs and other modalities.

Main Results:

  • Oncolytic viruses demonstrate significant anti-tumor effects in solid tumors.
  • Combination of OVs with immune checkpoint inhibitors (ICIs) can sensitize tumors resistant to immunotherapy.
  • Synergistic effects observed between OVs and chemotherapy, radiation, and other immune approaches (e.g., anti-PD1).

Conclusions:

  • Oncolytic virus combination therapy presents a promising new avenue for lung cancer treatment.
  • These combined approaches may overcome resistance to current therapies and improve efficacy.
  • Further research and clinical application of OV combination therapies are warranted for lung cancer patients.
Keywords:
OVs tumor vaccinecombination therapycombined immunizationlung canceroncolytic viruses (OVs)

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