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Atherogenic Index of Plasma (AIP) as a Long-Term Prognostic Factor Following CABG: Unveiling Insights From a

Abolfazl Salari1, Parvin Kalhor1, Ahmad Vakili-Basir1,2

  • 1Tehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran Iran.

Health Science Reports
|April 18, 2025
PubMed

Insights

The atherogenic index of plasma (AIP) predicts major adverse cerebro-cardiovascular events (MACCE), revascularization, and acute coronary syndrome (ACS) after coronary artery bypass grafting (CABG) surgery. AIP is a valuable and accessible prognostic tool for post-CABG patients.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Surgical Outcomes

Background:

  • The prognostic value of the atherogenic index of plasma (AIP) for major adverse cerebro-cardiovascular events (MACCE) after coronary artery bypass grafting (CABG) remains underexplored.
  • This study investigates AIP's predictive capability for MACCE and its components post-CABG.

Purpose of the Study:

  • To evaluate the atherogenic index of plasma (AIP) as a predictor of MACCE after CABG.
  • To assess AIP's role in predicting individual MACCE components, including acute coronary syndrome (ACS), cerebrovascular accident (CVA)/transient ischemic attack (TIA), revascularization, and all-cause mortality.

Main Methods:

  • A retrospective analysis of 23,432 patients undergoing isolated CABG.
  • Primary outcomes included all-cause mortality and MACCE (ACS, CVA/TIA, revascularization).
  • Stabilized Inverse Probability Weighting (IPW) and Proportional Hazard (PH) Cox regression were employed.

Main Results:

  • Higher AIP was significantly associated with increased MACCE risk (HR=1.05; p=0.006).
  • AIP independently predicted revascularization (HR=1.15; p=0.034) and ACS (HR=1.09; p=0.020).
  • AIP did not significantly predict all-cause mortality or CVA.

Conclusions:

  • The atherogenic index of plasma (AIP) is a significant predictor of MACCE, revascularization, and ACS following CABG.
  • AIP serves as a readily accessible and valuable prognostic biomarker for patients undergoing CABG surgery.
Abstract

Keywords:
atherogenic index of plasmacoronary artery bypass graftcoronary artery diseasemajor cardiovascular adverse event

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