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Long-Term Prognosis of Ischemic Stroke in Young Adults-A Single-Center Chinese Cohort Study

Yuhui Sha1, Qiqi Wang2, Mingyu Tang1

  • 1Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Brain and Behavior
|April 18, 2025
PubMed

Insights

Young adults with ischemic stroke face a significant risk of recurrence. Low education and prior stroke history are key predictors, highlighting the need for targeted prevention strategies.

Area of Science:

  • Neurology
  • Cerebrovascular Disease
  • Epidemiology

Background:

  • Young patients with ischemic stroke often have complex risk factors and prognoses.
  • Understanding long-term outcomes is crucial for this demographic.

Purpose of the Study:

  • To investigate the long-term prognosis of ischemic stroke in young adults.
  • To identify factors associated with recurrent events and poor functional outcomes.

Main Methods:

  • Prospective cohort study of 226 young adults (18-49 years) with ischemic stroke.
  • Follow-up via visits or phone; outcomes included recurrent events and modified Rankin Scale (mRS) score.
  • Kaplan-Meier and multivariate logistic analyses were employed.

Main Results:

  • The 5-year cumulative recurrence rate was 13.5%.
  • Independent predictors for recurrence included low education, prior TIA, prior ischemic stroke, and follow-up mRS score.
  • Baseline mRS score predicted long-term poor functional outcome.

Conclusions:

  • Young ischemic stroke patients are at risk for recurrence.
  • Low education level is a significant risk factor, especially in Chinese populations.
  • Enhanced stroke prevention and treatment are needed for young individuals.
Abstract

Keywords:
ischemic strokelong‐termprognosisrisk factorsyoung adults

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