Intraoperative examination in bone and soft tissue pathology

Intraoperative consultation is a vital tool in bone and soft tissue pathology. Cytologic and histologic interpretation within the clinical, radiologic, and surgical context is crucial for accurate analysis. This review highlights the most significant aspects of this procedure for evaluating musculoskeletal diseases. We outline the process and guide on determining differentiation lines in primary connective tissue neoplasms, assessing malignant potential, evaluating resection margins, investigating metastatic disease, and examining suppurative infections, particularly those associated with prosthetic materials. Furthermore, we summarize additional applications of the procedure.