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Related Concept Videos

Gross Anatomy of Bone01:17

Gross Anatomy of Bone

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The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in...
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Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
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Intraoperative examination in bone and soft tissue pathology.

Ali Alani1, Julio A Diaz-Perez2

  • 1Department of Pathology, Baylor University Medical Center, Baylor Scott & White Health, College of Medicine, Texas A&M University, Dallas, TX, USA.

Seminars in Diagnostic Pathology
|April 18, 2025
PubMed
Summary
This summary is machine-generated.

Intraoperative consultation provides critical insights for bone and soft tissue pathology diagnoses. This review details its use in evaluating musculoskeletal diseases, neoplasms, and infections for better patient outcomes.

Keywords:
Bone and soft tissue infectionBone neoplasmsConnective and soft tissue neoplasmsFrozen sections

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Area of Science:

  • Pathology
  • Oncology
  • Orthopedics

Background:

  • Intraoperative consultation is essential for timely diagnosis and treatment planning in bone and soft tissue pathology.
  • Accurate interpretation requires integrating cytologic, histologic, clinical, radiologic, and surgical information.

Purpose of the Study:

  • To review the key aspects of intraoperative consultation for musculoskeletal diseases.
  • To guide pathologists in evaluating neoplasms, margins, metastatic disease, and infections.

Main Methods:

  • Review of significant aspects of intraoperative consultation in musculoskeletal pathology.
  • Guidance on specific diagnostic challenges including differentiation, malignancy assessment, margin evaluation, and infection identification.

Main Results:

  • Highlights the crucial role of intraoperative consultation in managing bone and soft tissue conditions.
  • Provides a framework for assessing primary connective tissue neoplasms and metastatic disease.
  • Addresses the evaluation of suppurative infections, especially around prosthetic materials.

Conclusions:

  • Intraoperative consultation is indispensable for accurate diagnosis and management of musculoskeletal pathology.
  • The review offers practical guidance for pathologists, enhancing diagnostic precision and patient care.