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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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Related Experiment Video

Updated: May 11, 2025

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
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From geroscience to precision geromedicine: Understanding and managing aging.

Guido Kroemer1, Andrea B Maier2, Ana Maria Cuervo3

  • 1Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Inserm U1138, Université Paris Cité, Sorbonne Université, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Institut, Villejuif, France; Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.

Cell
|April 18, 2025
PubMed
Summary

Geroscience identifies aging mechanisms, viewing aging as influenced by gerogenes and gerosuppressors. This research targets precision geromedicine for tailored treatments based on individual aging biomarkers.

Keywords:
agingaging clocksanti-aging drugsatherosclerosiscancercardiovascular diseasesdiabetesepigenetic clocksgenomicsneurodegenerationoncogeneoncosuppressionprimary prevention

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Area of Science:

  • Gerontology and Molecular Biology
  • Geroscience and Aging Mechanisms

Background:

  • Significant advancements in understanding aging at molecular, cellular, and supracellular levels.
  • Emergence of geroscience focused on identifying actionable hallmarks of aging.

Purpose of the Study:

  • To define aging as a process influenced by gerogenes (promoting aging) and gerosuppressors (slowing aging).
  • To explore gerogenes and gerosuppressors as targets for modeling and treating age-related diseases.

Main Methods:

  • Utilizing new molecular profiling technologies to characterize gerogenic and gerosuppressive pathways.
  • Analyzing interactions between genetic, environmental, behavioral, and psychological factors in aging.

Main Results:

  • Identification of gerogenes and gerosuppressors associated with age-related diseases.
  • Characterization of these pathways as biomarkers of aging.
  • Establishing the foundation for precision geromedicine.

Conclusions:

  • Geroscience offers a framework for understanding and intervening in the aging process.
  • Precision geromedicine aims to tailor gerotherapeutics based on comprehensive individual profiles.
  • Future clinical trials and regulatory approval are anticipated for personalized aging interventions.