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Updated: May 11, 2025

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Published on: September 15, 2017
Primary Hyperaldosteronism: A Comprehensive Review of Pathophysiology, Diagnosis, and Treatment
Tarunya Vedere1, Maram Khalifa2
1Division of Endocrinology, Diabetes and Metabolism, UConn Health, 263 Farmington Avenue, Farmington, CT 06030, USA; Division of Endocrine Neoplasia, Neag Comprehensive Cancer Center, 263 Farmington Avenue, Farmington, CT 06030, USA.
Abstract:
Primary hyperaldosteronism (PA) is the most common endocrine cause of hypertension, characterized by autonomous aldosterone hormone production from the adrenal glands. It encompasses a wide spectrum of renin-independent aldosterone production with diverse histopathological etiologies. A vast majority of PA is caused by bilateral disease, remains underdiagnosed and is linked to serious cardiometabolic risks. This review outlines our current understanding of the etiopathogenesis of PA, and provides a comprehensive overview of the diagnostic strategies and management of PA.
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