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Magnetic Resonance Imaging01:24

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Multi-Center, Multi-Vendor Validation of Simultaneous MRI-Based Proton Density Fat Fraction and R2* Mapping Using a

Jitka Starekova1, David Rutkowski2, Won C Bae3

  • 1Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Journal of Magnetic Resonance Imaging : JMRI
|April 19, 2025
PubMed
Summary
This summary is machine-generated.

This study found excellent reproducibility for both proton density fat fraction (PDFF) and R2* quantification across multiple centers, vendors, and field strengths. Reproducibility slightly decreased with higher PDFF and R2* values, particularly for PDFF in high R2* conditions.

Keywords:
CSE‐MRIPDFFR2*phantomquantificationreproducibility

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Quantitative Imaging
  • Biomedical Engineering

Background:

  • Fat and iron deposition can affect MRI measurements like R2* and proton density fat fraction (PDFF).
  • The combined impact of these factors on the reproducibility of PDFF and R2* quantification is not well understood.

Purpose of the Study:

  • To assess the multi-center, multi-vendor reproducibility of PDFF and R2* quantification.
  • To evaluate these metrics using a specialized phantom designed to control fat and iron concentrations.

Main Methods:

  • A prospective, multi-center study utilizing a commercial PDFF-R2* phantom.
  • Phantom imaging was performed across four centers with different vendors at 1.5-T and 3-T using 3D multi-echo spoiled-gradient-echo sequences.
  • Two protocols were optimized for moderate and high R2* values, with statistical analysis including ICC, RDC, and RC.

Main Results:

  • Excellent agreement for PDFF (ICC=0.97) and R2* (ICC=0.99) was observed across centers, vendors, field strengths, and protocols.
  • Reproducibility for PDFF was excellent (ICC=0.96-0.99) and for R2* was strong (ICC=0.988-0.99), though variability increased with higher PDFF and R2* values.
  • Stability tests showed near-perfect reproducibility for both PDFF and R2* (ICC=1.0).

Conclusions:

  • High reproducibility of PDFF and R2* quantification is achievable across diverse MRI settings.
  • Acquisition protocols and phantom characteristics significantly influence the precision of these quantitative MRI measures.
  • The findings support the reliable use of PDFF and R2* in multi-center research and clinical applications.