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Vessel-sparing Excision and Primary Anastomosis

Vessel-sparing Excision and Primary Anastomosis

Published on: January 7, 2019

A Predictive Model for the Risk of Procedural Failure in Retrograde Ureteral Stenting for Malignant Extrinsic

Shuhan Liu¹, Jing Wang², Zongyao Hao³

¹Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; Department of Urology Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.

|April 19, 2025

Summary

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This summary is machine-generated.

This study identifies key predictors of procedural failure in retrograde ureteral stenting (RUS) for malignant extrinsic ureteral obstruction (MEUO). A validated nomogram helps predict RUS failure risk, aiding treatment decisions.

Area of Science:

Urology
Oncology
Medical Imaging

Background:

Malignant extrinsic ureteral obstruction (MEUO) poses challenges for retrograde ureteral stenting (RUS).
Predicting procedural failure in RUS is crucial for optimizing patient management.

Purpose of the Study:

To identify risk factors for procedural failure in RUS for MEUO.
To develop and validate a predictive model (nomogram) for RUS procedural failure.

Main Methods:

Retrospective analysis of 100 RUS cases (50 success, 50 failure) from 2020-2024.
Logistic regression to identify predictors of RUS failure.
Nomogram development and validation using ROC analysis on 40 additional cases.

Main Results:

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Predictors of RUS failure include obstruction length >3 cm, ureteral orifice violation, ureter invasion, and prior radiotherapy.
A nomogram exceeding 120 points indicates substantial RUS failure risk.
The nomogram demonstrated high predictive accuracy (AUC 0.894 training, 0.919 validation).

Conclusions:

The developed nomogram is a valuable tool for predicting RUS procedural failure in MEUO patients.
This tool assists clinicians and patients in selecting appropriate treatments for MEUO.