[Honney Allergy]

The main cause of allergy to honey is linked to the head of the bee.

A 44-year-old man with no relevant history presented with pharyngeal, palmo-plantar and axillary itching, dysphagia, dizzinessa nd sweating after ingesting honey. Addiotionally, when he drinks banana yogurt and cow's milk smoothie he notices slight pharyngeal itching. Normal basal tryptase (5.03 ug/L), total IgE 212.2 kU/L, IgEs: honey 37.3 and Apis 0.69 kU/L. SDS-PAGE and immunoblot of honey and banana yogurt extracts with the presence of bands between 12 to 70 kDa (honey); 12 to 35 kDa (banana yogurt) and SDS-PAGE and immunoblot of bee venom extract with the presence of bands from 10 to 50 kDa and the patient's serum recognized two proteins: one compatible with the major allergen Api m 1 at 16 kDa and another compatible with Api m 11 at 50 kDa.

The patient is sensitized to several honey proteins (2 between 50-75 kDa and 1 between 20-25 kDa). He doesn't recognize any protein in the banana yogurt. Additionally, the patient recognizes a bee venom protein of about 50 kDa (compatible with Api m 11), and this may be the primary sensitization pathway.