Chemical safety screening of products - better proactive

The increasing pressure to ensure product safety in a global market comes up against the current practice of targeting only known hazardous compounds in product safety analysis. However, product safety refers not only to known but also to unknown or hidden hazards that are very important to know and avoid. Shortcomings and limitations of currently used technologies seem to cause an obvious discrepancy between intended and actual consumer protection. Products are not as safe as claimed by stakeholders. An existing but overlooked proactive safety screening with a prioritization strategy is brought into focus as it offers a unique solution. It can handle the complexity of a product with thousands of compounds of unknown identity and unknown toxicity and can figure out the important hazardous compounds, both known and unknown. Using hardly any sample preparation and the effect detection at an early position in the workflow is a game changer not to overlook hazardous compounds. All analytical technologies are needed, but the key is the re-arrangement of the instrument order, i.e. firstly hazard-related screening (effect first) and secondly, focus on identification of prioritized hazardous compounds. Such a proactive safety screening revealed previously unknown hazardous compounds in products on the market claimed to be safe. The highly sustainable, affordable, and all-in-one 2LabsToGo-Eco with easy-to-use planar bioassays empowers stakeholders to implement proactive safety screening and dynamic risk management. The transition to greater efficacy in consumer protection needs incentives and the critical review aims to stimulate a debate.