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Genetic insights into neuroblastoma: the role of immune cell features
Yunfei Ma1, Qiang He1, Yan Su2
1Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Objective:
To elucidate the causal relationship between immune cells and neuroblastoma, we conducted a two-sample Mendelian randomization (MR) analysis.
Materials And Methods:
The exposure and outcome data for the genome-wide association study (GWAS) used in this research were sourced from an open-access database. The study utilized two-sample MR analysis to evaluate the causal relationship between 731 immune cell features and neuroblastoma. The main approach to explore this relationship is to apply the inverse variance weighting (IVW) method. In addition, sensitivity analyses including leave-one-out analysis, Cochran's Q test, Mendelian randomization Egger method (MR-Egger) intercept test and Mendelian randomization pleiotropy residual sum and outlier test (MR-PRESSO) were performed to verify the reliability of the MR results.
Results:
The study identifies five immune cell traits as causally contributing to neuroblastoma risk, including CD3- lymphocyte (% of leukocytes) (IVW: OR[95 % CI] 0.65[0.42-0.99], P = 0.0469), CD86 on granulocyte (IVW: OR[95 % CI] 0.61[0.41-0.92], P = 0.0167), FSC-A on granulocyte(IVW: OR[95 % CI] 0.73[0.57-0.93], P = 0.0117), HLA DR+ CD8+ T cell Absolute Count(IVW: OR[95 % CI]: 1.38[1.01-1.88], P = 0.0408), IgD- CD38+ B cell Absolute Count(IVW: OR[95 % CI] 0.42[0.27-0.66], P = 0.0002). The results of sensitivity analyses were consistent with the main findings.
Conclusion:
We demonstrated a close causal relationship between specific types of immune cells and neuroblastoma by genetic methods, offering valuable guidance for future clinical studies.
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