The association between pulse wave velocity and cerebrospinal fluid biomarkers for Alzheimer's disease

We examined the association between arterial stiffness using non-invasive pulse wave velocity (PWV) and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. We conducted a cross-sectional multivariate logistic regression analysis using established cut-off values for PWV and CSF biomarkers. Of the 739 participants, 69% were female, 84% were White, 12% were Black, and the mean age was 62. After adjustment for potential confounders, participants with high PWV had 94% (OR = 1.94, 95% CI 1.20-3.20) greater odds of AD biomarker positivity for tTau/Aβ₄₂ and 108% (OR = 2.08, 95% Cl, 1.27-3.46) for pTau181/Aβ₄₂. Our results suggest that higher arterial stiffness is associated with AD CSF biomarker positivity.