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Related Concept Videos

Temperature Measurement Sites01:14

Temperature Measurement Sites

1.4K
A thermometer measures body temperature. The common sites for measuring body temperature are the oral cavity, axillary region, temporal artery, and skin surface, such as the forehead, abdomen, and axilla. True core body temperature is assessed in the rectum, tympanic membrane, pulmonary artery, esophagus, and urinary bladder.
Oral: When assessing oral temperature, the thermometer tip should be placed under the tongue in the posterior sublingual pocket. It offers accurate readings and can be...
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Time-Resolved Ratiometric Fluorescence Nanothermometer for Real-Time Endoscopic Temperature Guidance during Tumor

Lei Chen1, Jiamiao Yin1, Yiran Wang2

  • 1Department of Chemistry & Academy for Engineering and Technology, Fudan University, Shanghai, 200441, China.

Advanced Materials (Deerfield Beach, Fla.)
|April 21, 2025
PubMed
Summary
This summary is machine-generated.

A novel time-resolved ratiometric fluorescence nanothermometer enables accurate real-time temperature imaging for thermal ablation. This technology improves precision in cancer treatment by overcoming challenges in signal extraction within biological tissues.

Keywords:
endoscopeeuropium complexfluorescence nanothermometerimage‐guided surgeryin vivo temperature imagingthermal ablation

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Optical Imaging

Background:

  • Thermal ablation is a key cancer treatment, but lacks real-time temperature feedback, risking incomplete or excessive ablation.
  • Existing ratiometric nanothermometers struggle with in vivo signal accuracy due to tissue optical properties and autofluorescence.

Purpose of the Study:

  • To develop a time-resolved ratiometric fluorescence nanothermometer for accurate in vivo temperature imaging.
  • To create a fluorescence temperature endoscopy system for precise intraoperative guidance during thermal ablation.

Main Methods:

  • Synthesized a europium and iridium complex nanothermometer with distinguishing fluorescence lifetimes for time-resolved ratiometry.
  • Utilized a 450 nm excitation source with high quantum yield (57.8%) for efficient signal generation.
  • Developed a time-resolved ratiometric method for signal extraction in complex biological samples (blood, tissue phantoms).

Main Results:

  • Achieved accurate temperature imaging in whole blood, 2 cm tissue phantom, and 5 mm pork slice.
  • Demonstrated exceptional thermal sensitivity (6.9% K⁻¹) and high temperature resolution (0.02 K) within a 30-96 °C range.
  • Developed a 10 fps fluorescence temperature endoscopy system for real-time monitoring during rabbit liver tumor microwave ablation.

Conclusions:

  • The time-resolved ratiometric nanothermometer overcomes in vivo signal extraction challenges for precise thermal ablation monitoring.
  • The developed fluorescence endoscopy system enables accurate, real-time temperature imaging for improved intraoperative guidance.
  • This technology offers a promising new approach for enhancing the safety and efficacy of minimally invasive cancer treatments.