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Antipsychotic-Induced Ogilvie Syndrome: A Case Report
José Ribeiro1, Rafaela Lopes Freitas1, Sandra Oliveira Mendes1
1Internal Medicine Service, Hospital Pedro Hispano, Matosinhos, PRT.
Cureus
|April 21, 2025
Summary
Antipsychotic medications can cause severe gastrointestinal hypomotility (GIH), leading to serious complications. Early recognition and prevention strategies are crucial for managing this adverse effect.
Area of Science:
- Gastroenterology
- Pharmacology
- Critical Care Medicine
Background:
- Gastrointestinal hypomotility (GIH) is an underrecognized adverse effect of antipsychotic medications.
- Antipsychotic use, particularly with first- and second-generation agents, can precipitate severe GI complications.
Observation:
- A 37-year-old male with schizophrenia presented with acute abdominal pain, distension, and signs of shock.
- Imaging revealed bowel distension without obstruction, and laboratory tests showed inflammation, acute kidney injury, and hyperlactatemia.
Findings:
- The patient rapidly deteriorated, requiring emergent laparotomy for abdominal compartment syndrome.
- Intraoperative findings included bowel distension and unviability, necessitating a total colectomy.
Implications:
- This case highlights a severe manifestation of antipsychotic-induced GIH.
- Emphasizes the need for heightened awareness, prevention, and prompt recognition of GIH in patients on antipsychotics.
Keywords:
abdominal compartment syndromeadverse effectsantipsychoticsgastrointestinal hypomotilityschizophreniaMore Related Videos
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