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Updated: May 10, 2025

Simple, Affordable, and Modular Patterning of Cells using DNA
Published on: February 24, 2021
Immobilizing and Patterning DNA on Simplified Protein-Free DNA-Based Lateral Flow Assays
Hyunbin Lee1,2, Haesoo Hwang1,2, Ji Young Lee3
1Department of Materials Science and Engineering, College of Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
Abstract:
This work presents a comprehensive study on DNA-based LFAs that completely avoids the use of proteins or pretreatment buffer. We address key fundamental challenges including optimizing buffer conditions for effective DNA immobilization on paper, understanding sequence-dependent detection, and ultimately developing patterning techniques that allow DNA patterns to appear on paper that exhibit distinct shapes depending on the introduced input sequences.

