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Clindamycin levels in reproductive tissues.

S R Johnson, C R Petzold, R P Galask

    American Journal of Reproductive Immunology and Microbiology : AJRIM
    |June 1, 1985
    PubMed
    Summary
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    Intravenous clindamycin phosphate achieves significant tissue concentrations in female reproductive organs. These levels exceed minimal inhibitory concentrations, supporting its use for obstetric and gynecologic anaerobic infections.

    Area of Science:

    • Pharmacology
    • Obstetrics and Gynecology
    • Infectious Diseases

    Background:

    • Clindamycin is a common treatment for obstetric and gynecologic infections.
    • Anaerobic bacteria are frequent pathogens in these infections.
    • Genital organ tissue levels of clindamycin after IV administration are not well-documented.

    Purpose of the Study:

    • To quantify clindamycin concentrations in various female reproductive tissues.
    • To assess the therapeutic relevance of these tissue levels.

    Main Methods:

    • Ten women received a single 600 mg IV infusion of clindamycin phosphate.
    • Tissue specimens (cervix, uterus, fallopian tube, ovary) were collected during surgery.
    • Clindamycin levels in serum and tissue were measured.

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    Main Results:

    • Mean clindamycin levels: cervix (2.63 µg/ml), endometrium (5.58 µg/ml), myometrium (2.39 µg/ml), fallopian tube (2.96 µg/ml), ovary (3.74 µg/ml).
    • Mean serum level was 6.26 µg/ml.
    • All measured tissue concentrations surpassed the minimal inhibitory concentration for anaerobes.

    Conclusions:

    • Intravenous clindamycin phosphate effectively penetrates obstetric and gynecologic tissues.
    • Achieved concentrations support clindamycin's efficacy against anaerobic pathogens in these sites.