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Updated: May 10, 2025
Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
Retinal Oxygen Kinetics and Hemodynamics in Choroidal Melanoma After Iodine-125 Plaque Radiotherapy Using a Novel
Haihan Zhang1, Jingyuan Zhu1, Yueming Liu1
1Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Iodine-125 plaque radiotherapy for choroidal melanoma significantly alters retinal oxygen and blood flow dynamics. These changes highlight the need for early detection of microvascular complications to preserve vision.
Area of Science:
- Ophthalmology
- Medical Imaging
- Radiation Oncology
Background:
- Choroidal melanoma (CM) is a rare intraocular tumor.
- Iodine-125 plaque radiotherapy (PRT) is a common treatment for CM.
- Understanding the long-term effects of PRT on retinal vasculature is crucial.
Purpose of the Study:
- To investigate changes in retinal oxygen kinetics and hemodynamics in CM patients.
- To evaluate these changes within a 2-year period before and after iodine-125 PRT.
- To utilize a novel noninvasive structure-functional imaging analysis system.
Main Methods:
- Employed a novel, noninvasive imaging system integrating multispectral imaging (MSI) and laser speckle contrast imaging (LSCI).
- Acquired vascular structural, hemodynamic, and oxygenation metrics.
- Conducted follow-ups at baseline, 1, 3, 6, 12, 18, and 24 months post-PRT.
Main Results:
- Significant decreases in retinal arterial oxygen concentration, saturation, utilization, and metabolism were observed post-PRT.
- Increased systolic time, acceleration time index (ATI), and resistivity index (RI) were noted, with ATI and RI significantly higher than controls.
- Baseline elevated mean arterial blood flow velocity (BFVa) and retinal blood flow (RBFa) in CM eyes decreased over time post-PRT.
Conclusions:
- Iodine-125 PRT induces significant retinal and vascular changes in CM patients.
- There is a need for rapid screening of radiation-induced microvascular complications.
- Timely interventions are required to protect visual function in treated patients.
