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Growth hormone and aging: a clinical review
Luis E Fernández-Garza1,2,3, Fernando Guillen-Silva1,3, Marcos A Sotelo-Ibarra1,4
1Innbiogem SC, Monterrey, Mexico.
Frontiers in Aging
|April 22, 2025
Summary
Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) show potential for anti-aging, influencing metabolism and body composition. However, their long-term safety and effectiveness for healthy aging require further investigation.
Area of Science:
- Gerontology and Endocrinology
- Molecular Biology and Aging Research
Background:
- Aging is a natural process involving functional decline and increased disease risk.
- Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are key regulators of physiological processes.
- Aging therapies targeting GH/IGF-1 axis are being explored to counteract age-related changes.
Purpose of the Study:
- To review the molecular mechanisms of GH in aging.
- To evaluate the potential of GH and IGF-1 as anti-aging therapies.
- To examine clinical trial findings, adverse effects, and controversies surrounding these therapies.
Main Methods:
- Literature review of molecular mechanisms of GH.
- Analysis of GH/IGF-1 roles in age-related physiological changes.
- Synthesis of clinical trial data on GH/IGF-1 for aging.
Main Results:
- GH influences body composition, metabolism, endothelial function, and cognition.
- Some studies suggest benefits of GH/IGF-1 therapies in aging.
- Potential adverse effects and limitations are associated with these therapies.
Conclusions:
- GH and IGF-1 have multifaceted roles relevant to aging.
- While promising, the long-term safety and efficacy of GH/IGF-1 therapies for healthy aging are not yet established.
- Further research is crucial to clarify the role and application of these hormones in aging.
Keywords:
aginganti-aging treatmentshuman growth hormonehuman growth hormone deficiencyinsulin-like growth factor IMore Related Videos
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