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Related Experiment Video

Updated: May 8, 2025

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

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Published on: October 20, 2020

Polypept(o)ide-Based Core-Shell Bottlebrush Polymers: A Versatile Platform for Drug Encapsulation.

Bonan Zhao¹, Jingyuan Wei¹, Rüdiger Berger²

¹Leiden Academic Center for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden, 2333CC, The Netherlands.

Macromolecular Bioscience

|April 22, 2025

Summary

This summary is machine-generated.

This study introduces novel core-shell brushes (CSBs) synthesized from polypept(o)ides, demonstrating their potential as nanomedicine platforms. These versatile nanoparticles effectively encapsulate and release the drug dasatinib, showing therapeutic efficacy in glioblastoma cells.

Keywords:

core–shell bottlebrush polymers drug delivery polypept(o)ide “grafting‐from” synthesis

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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Area of Science:

Polymer Chemistry
Nanotechnology
Materials Science

Background:

Cylindrical bottlebrush polymers (CBPs) offer tunable nanoparticle properties via synthesis.
Block copolymer side chains facilitate the creation of core-shell nanostructures.

Purpose of the Study:

To synthesize polypept(o)ide-based core-shell CBPs (CSBs) using a "grafting-from" approach.
To evaluate the potential of these CSBs as a platform for drug encapsulation and delivery.

Main Methods:

Synthesized core-shell brushes (CSBs) with a poly-lysine (pLys) backbone and poly(γ-benzyl-l-glutamic acid)-block-polysarcosine (pGlu(OBn)-b-pSar) side chains.
Characterized CSB size, molecular weight, and dispersity using size-exclusion chromatography.
Investigated drug loading, release kinetics, cellular uptake, and therapeutic efficacy using dasatinib as a model drug.

Main Results:

Successfully synthesized CSBs with tunable hydrodynamic radii (17-70 nm) and high molecular weights (1320-4000 kg mol⁻¹).
Achieved 10% loading efficiency for dasatinib, with sustained release over 72 hours.
Demonstrated cellular uptake into U-87 MG glioblastoma cells and drug-related therapeutic effects.

Conclusions:

Polypept(o)ide-based CSBs represent a promising platform for nanomedicine applications.
The developed CSBs show potential for targeted drug delivery and cancer therapy.
Further optimization, such as covalent drug attachment, could enhance drug release profiles.