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Foselutoclax (UBX1325) for Diabetic Macular Edema - A Potential Novel Therapy?

Emily Y Chew1

  • 1Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD.

NEJM Evidence
|April 22, 2025
PubMed
Abstract

No abstract available in PubMed .

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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