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Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis
Shasha Zhang1,2, Hairong Xiao3,4, Yanqin Lin3,4
1State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology-Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China. zhangshasha@seu.edu.cn.
Neuroscience Bulletin
|April 22, 2025
Summary
Sensorineural hearing loss (SNHL) involves cochlear cell death. Novel programmed cell death (PCD) pathways like ferroptosis, necroptosis, and pyroptosis are key mechanisms in SNHL, offering new therapeutic targets.
Area of Science:
- Oto-neuroscience
- Cellular Biology
- Pathology
Background:
- Sensorineural hearing loss (SNHL) is the most common form of hearing impairment.
- It results from damage or loss of cochlear hair cells and spiral ganglion neurons.
- Acquired SNHL is linked to factors like ototoxic drugs, noise, aging, infections, and diseases.
Purpose of the Study:
- To review programmed cell death (PCD) pathways involved in SNHL.
- To highlight the roles and mechanisms of novel PCD pathways (ferroptosis, necroptosis, pyroptosis) in SNHL.
- To explore potential therapeutic strategies for SNHL by targeting these PCD pathways.
Main Methods:
- Literature review and synthesis of existing research on PCD and SNHL.
- Analysis of mechanisms underlying ferroptosis, necroptosis, and pyroptosis in the context of SNHL.
- Identification of potential therapeutic targets within these PCD pathways.
Main Results:
- Several PCD pathways, including ferroptosis, necroptosis, and pyroptosis, are implicated in SNHL.
- These pathways contribute to the injury and loss of cochlear cells.
- Understanding these mechanisms provides a basis for novel therapeutic interventions.
Conclusions:
- Novel PCD pathways play a significant role in the pathogenesis of SNHL.
- Targeting ferroptosis, necroptosis, and pyroptosis presents promising avenues for SNHL treatment.
- Further research into these pathways could lead to effective SNHL therapies.
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