Nitrogen-Based Organofluorine Functional Molecules: Synthesis and Applications

Area of Science:

• Organic Chemistry
• Medicinal Chemistry
• Material Science

Background:

• Fluorine and nitrogen chemistry has a rich history.
• Recent progress in catalysis and photochemistry has driven significant interest in this field over the past two decades.

Purpose of the Study:

• To provide an updated review of the synthesis and applications of nitrogen-based organofluorine functional molecules.
• To cover contributions from 2015 to 2023, focusing on organic synthesis and medicinal chemistry.

Main Methods:

• Categorization of fluorine-containing reagents based on nitrogen-bound fluorine groups (N-F, N-RF, N-SRF, N-ORF).
• Review of nitrogen-linked fluorine-containing building blocks, catalysts, pharmaceuticals, and agrochemicals.

Main Results:

• Detailed overview of various fluorine-containing reagents and their synthetic utility.
• Demonstration of the broad applicability and growing importance of these compounds.

Conclusions:

• Fluorine-nitrogen chemistry is a rapidly advancing field with significant impact.
• These organofluorine molecules are essential components in modern chemical synthesis and drug discovery.