Quantitative study on whole brain volume in patients with obstructive sleep apnea based on synthetic magnetic resonance imaging
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Updated: May 11, 2026
Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Yanpeng Li1,2, Xiaomeng Du3, Xiaoyan Lang1
1Department of Medical Imaging, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
Objective:
To apply SyMRI to quantify whole brain volume changes in patients with varying degrees of obstructive sleep apnea (OSA).
Methods:
A total of 49 untreated adult patients diagnosed with OSA via polysomnography (PSG) at our hospital were included in this study. Among these patients, 21 were categorized into the mild-to-moderate OSA group, and 28 into the severe OSA group. Additionally, 31 healthy adults were recruited as the healthy control (HC) group. SyMRI post-processing software was used to obtain whole brain volume segmentation values.
Results:
In terms of the STOP-BANG questionnaire, the score of the severe OSA group was significantly higher than that of the mild-to-moderate OSA group (P < 0.05). Compared with the HC group, the mild-to-moderate OSA group and the severe OSA group exhibited a reduction in N3-stage sleep (both P < 0.05). Post-hoc multiple comparisons showed that compared with the HC group, the severe OSA group had increased GMV, BPV, and ICV, while the mild-to-moderate OSA group showed an increase in CSFV (P < 0.05). Additionally, compared with the HC group, the mild-to-moderate OSA group exhibited a decrease and the severe OSA group showed an increase in MYV (P < 0.05). Multiple comparisons of normalized volume fractions revealed that GMF, WMF, CSFF, MYF and BPVF were significantly different between the HC group and OSA groups (all P < 0.05).
Conclusion:
The brain volume parameters generated from SyMRI can quantify the degree of brain injury in patients with OSA.
Clinical Trial Number:
Not applicable.
