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Updated: May 10, 2025

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
Published on: November 18, 2015
A new coumarin from Tridax procumbens L. as potential anticancer, antibacterial, antioxidant agent and its molecular
Varsharani V Ingole1,2, Pravin C Mhaske3, Siraj B Shaikh4
1Department of Chemistry, PES's Modern College of Arts, Science and Commerce, Pune, India.
Abstract:
A study investigated the phytochemical constituent of the methanol extract from the aerial part of T. procumbens L. The investigation resulted in the identification of a new coumarin. A novel coumarin compound was successfully isolated using the silica gel column chromatographic technique and various spectroscopic methods were employed to elucidate its structure. Isolated new coumarin was evaluated for its cytotoxicity, antimicrobial, and antioxidant activities. The isolated coumarin exhibited cytotoxicity IC50 values of 4.92 and 5.99 µg/mL against MCF-7 and MDA-MB-249 cell lines, respectively, in the MTT assay. Additionally, the compound demonstrated notable antioxidant activity, with an IC50 value of 1.36 µg/mL (p < 0.05). The antimicrobial evaluation revealed MIC values of 125 µg/mL against S. aureus and 31.5 µg/mL against P. aeruginosa. This activity is strongly supported by an in silico study. Further studies are required to determine its effectiveness as an antioxidant, anticancer, and antibacterial agent.
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