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Comprehensive View of Magnesium Physiology
Shagufta Jawaid1, Samya Shams1, Damini Kharb1
1Department of Pharmacy Practice, School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Dehradun, Uttarakhand, India.
Endocrine, Metabolic & Immune Disorders Drug Targets
|April 23, 2025
Summary
Magnesium (Mg) is a vital electrolyte, crucial for numerous biological processes. Recent research highlights its importance in human health, revealing new therapeutic potentials for Mg imbalances like hypomagnesemia.
Area of Science:
- Biochemistry and Physiology
- Human Health and Disease
Background:
- Inorganic ion and fluid balance are well-studied, but magnesium (Mg) has been historically underappreciated despite its critical role.
- Lack of detailed knowledge on subcellular and systemic Mg regulation contributed to its underuse.
- Recent advancements in identifying Mg channels and understanding Mg homeostasis have renewed scientific interest.
Purpose of the Study:
- To review the latest advancements in magnesium's physiological functions and homeostasis.
- To emphasize hypomagnesemia as a key clinical manifestation of Mg imbalance.
- To explore the therapeutic potential of magnesium in human health.
Main Methods:
- Comprehensive review of recent scientific literature and technological advancements.
- Analysis of physiological functions, Mg transporters, and renal mechanisms in Mg homeostasis.
- Investigation of Mg deficiency, its interplay with other electrolytes, and diagnostic approaches.
Main Results:
- Magnesium plays a multidimensional role in various biological processes.
- Hypomagnesemia is the most common clinical sign of magnesium imbalance.
- Understanding Mg regulation offers new therapeutic insights and potential treatments.
Conclusions:
- Magnesium is an essential electrolyte with significant implications for human health.
- Further research into Mg homeostasis and deficiency is crucial for clinical practice.
- Magnesium supplementation shows therapeutic promise for various medical conditions.
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