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The clinical risk and post-COVID-19 sequelae in patients with myasthenia gravis: a retrospective observational study

Chaoyue Zhang1, Haocheng Luo1, Yufei Deng1

  • 1The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China.

Frontiers in Neurology
|April 23, 2025
PubMed

Insights

Myasthenia gravis (MG) patients face severe COVID-19, linked to corticosteroid dose and prior crises. They also experience prolonged post-COVID-19 symptoms like insomnia and myalgia.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Limited data exists on post-COVID-19 sequelae in myasthenia gravis (MG) patients.
  • Previous studies focused on COVID-19 infection severity in MG patients.
  • This study investigates long-term outcomes and influencing factors for MG patients post-COVID-19.

Purpose of the Study:

  • To analyze factors affecting COVID-19 severity in MG patients.
  • To identify and track post-COVID-19 sequelae in MG patients at 1 and 12 months.
  • To understand the long-term prognosis of MG patients after COVID-19 infection.

Main Methods:

  • Retrospective analysis of 150 MG patients with COVID-19 infection.
  • Data collection included demographics, clinical characteristics, and post-COVID-19 sequelae.
  • Multivariable logistic regression and McNemar's test were used for analysis.

Main Results:

  • COVID-19 severity in MG patients correlated with daily corticosteroid dose and pre-COVID-19 myasthenia crises frequency.
  • 85.3% of MG patients experienced COVID-19 infection, with 18% hospitalized.
  • MG patients showed higher prevalence of sequelae like insomnia, myalgia, dizziness, and cough at 12 months post-recovery.

Conclusions:

  • MG patients are susceptible to severe COVID-19, influenced by corticosteroid use and crisis history.
  • Post-COVID-19 sequelae, including neurological and respiratory symptoms, persist in MG patients at 12 months.
  • Findings highlight the need for monitoring and managing long-term health in MG patients after COVID-19.
Abstract

Keywords:
coronavirus infectionsmyasthenia gravispersistent infectionpost COVID-19 syndromesequelae

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