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Related Concept Videos

Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...
Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Exercise and Muscle Performance01:27

Exercise and Muscle Performance

Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
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Healing I: Introduction01:11

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

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Related Experiment Video

Updated: Jun 24, 2026

Fabrication of Myogenic Engineered Tissue Constructs
13:43

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Bioengineered Constructs as a Tissue Engineering-Based Therapy for Volumetric Muscle Loss.

Surendrasingh Y Sonaye1, Prabaha Sikder1

  • 1Department of Mechanical Engineering, Cleveland State University, Cleveland, Ohio, USA.

Tissue Engineering. Part B, Reviews
|April 23, 2025
PubMed
Summary

Skeletal muscle tissue engineering offers promising solutions for volumetric muscle loss injuries. Advanced biofabrication and machine learning are key to developing effective regenerative constructs for functional muscle restoration.

Keywords:
biomaterialsbioprintingconstructsmachine learningskeletal muscle tissue engineeringvolumetric muscle loss

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Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation
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Last Updated: Jun 24, 2026

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In Vivo Functional Assessment of Rat Masseter Muscle Following Surgical Creation of a Volumetric Muscle Loss (VML) Injury
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In Vivo Functional Assessment of Rat Masseter Muscle Following Surgical Creation of a Volumetric Muscle Loss (VML) Injury

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214

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Tissue Engineering

Background:

  • Volumetric muscle loss (VML) injuries cause significant functional deficits due to insufficient natural regeneration.
  • Current treatments like autologous tissue transfer have limited efficacy and risks.
  • Skeletal muscle tissue engineering (SMTE) presents a viable alternative for functional muscle regeneration.

Purpose of the Study:

  • To critically review recent therapeutic strategies in SMTE for VML.
  • To evaluate bioengineered constructs, focusing on 3D bioprinting and machine learning integration.
  • To identify current challenges and future directions in functional muscle restoration.

Main Methods:

  • Review of recent literature on SMTE and biofabrication techniques.
  • Analysis of various biomaterials and construct designs for muscle regeneration.
  • Evaluation of 3D bioprinting and machine learning applications in SMTE.

Main Results:

  • Bioengineered constructs, particularly those from 3D bioprinting, show potential for mimicking native muscle architecture.
  • Machine learning aids in optimizing construct design and predicting cellular responses.
  • Significant progress has been made, but challenges in structural complexity, fibrosis, vascularization, and innervation persist.

Conclusions:

  • SMTE, especially with advanced biofabrication and AI, holds promise for VML treatment.
  • Overcoming challenges in replicating native tissue complexity and achieving full functional integration is crucial.
  • Future research must focus on translational, scalable, and clinically applicable regenerative strategies for point-of-care use.