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Emerging therapies and current standards in pulmonary carcinoid management
Danielle I Aronowitz1, Kevin Hyman
1Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Northwell Health, New Hyde Park, New York, NY, USA.
Current Opinion in Pulmonary Medicine
|April 23, 2025
Summary
Pulmonary carcinoid tumors, though rare, are increasingly managed with therapies beyond surgery. Advanced treatments include hormonal, cytotoxic, radiation, and endobronchial strategies tailored by a multidisciplinary team.
Area of Science:
- Pulmonology
- Oncology
- Pathology
Background:
- Pulmonary carcinoid tumors are rare lung neoplasms with distinct characteristics.
- Understanding their unique histopathology and clinical presentation is crucial for effective management.
Purpose of the Study:
- To review the presentation and management of pulmonary carcinoid tumors.
- To highlight recent clinical trials for advanced and metastatic disease.
Main Methods:
- Literature review focusing on presentation, histopathology, and treatment strategies.
- Analysis of recent clinical trials in advanced and metastatic pulmonary carcinoid tumor management.
Main Results:
- Surgical resection is primary for localized and locoregionally spread tumors.
- Systemic hormonal/cytotoxic therapies, radiation, and endobronchial approaches are expanding treatment options.
- Treatment decisions depend on tumor stage, burden, patient status, and surgical tolerance.
Conclusions:
- Pulmonary carcinoid tumor management has evolved beyond surgical resection.
- Novel systemic therapies, radiation, and endobronchial interventions offer new avenues.
- Personalized treatment plans require a multidisciplinary team approach.
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