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Novel specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil in duplex DNA
Hidetaka Torigoe1, Kei Hirabayashi1, Saki Adachi1
1Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. htorigoe@rs.tus.ac.jp.
Abstract:
Only mercury(II) and silver(I) ions are known to specifically bind to natural and naturally modified base pairs in duplex DNA to form metal-mediated base pairs. We found novel, specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil (FdU) in duplex DNA, forming C-Cu-FdU and FdU-Cu-C base pairs.
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