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[Mpox clade Ib: an inescapable global threat].

David Alejandro Cabrera-Gaytán1, Alfonso Vallejos-Parás2, Lumumba Arriaga-Nieto2

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In 2024, the Democratic Republic of Congo reported 92% of Africa's mpox cases, predominantly affecting children under 15. This editorial questions the heterosexual transmission dynamics of the Clade I, variant Ib mpox outbreak.

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Disease OutbreaksMpox

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Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Public Health

Background:

  • The 2024 mpox outbreak in Africa, particularly the Democratic Republic of Congo (DRC), shows a high concentration of cases.
  • A significant majority (92%) of African mpox cases originated from the DRC.
  • Children under 15 years old constitute a substantial portion (66%) of diagnosed individuals in this outbreak.

Discussion:

  • The current outbreak involves Clade I of the mpox virus, specifically variant Ib.
  • Evidence suggests a notable prevalence of heterosexual transmission in this particular mpox outbreak.
  • This editorial raises critical questions regarding the epidemiological characteristics and transmission patterns observed.

Key Insights:

  • The DRC is the epicenter of the 2024 African mpox outbreak.
  • Juveniles under 15 are disproportionately affected by this mpox outbreak.
  • Heterosexual transmission appears to be a significant factor in the current Clade I, variant Ib mpox spread.

Outlook:

  • Further research is needed to understand the specific drivers of mpox in the DRC.
  • Investigating the role of heterosexual transmission is crucial for effective public health interventions.
  • Monitoring Clade I, variant Ib mpox dynamics is essential for global health security.