Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polysorbate 80: a pharmacological study.

R K Varma, R Kaushal, A Y Junnarkar

    Arzneimittel-Forschung
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Sexual Function After Obstetric Anal Sphincter Injuries (OASIs): A Systematic Review and Meta-Analysis.

    International urogynecology journal·2026
    Same author

    Care pathways and anorectal evaluation for obstetric anal sphincter injury-related incontinence: A UK survey of obstetricians.

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2025
    Same author

    The impact of co-occurring tumor suppressor mutations with mEGFR as early indicators of relapse in lung cancer.

    ESMO open·2025
    Same author

    To Evaluate the Success of Sialendoscopy Assisted Intraoral Approach for Removal of Submandibular Hilar Stones.

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2025
    Same author

    Neoadjuvant Chemotherapy and Low Dose Immunotherapy in Resectable Non-small Cell Lung Cancer: A Multi-center Retrospective Cohort Analysis.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2025
    Same author

    Allometric scaling and carbon sequestration in agroforestry species of the Western Himalayas: a model-based approach.

    Environmental monitoring and assessment·2025
    Same journal

    Wirksamkeit und Verträglichkeit eines pflanzlichen Arzneimittels mit Kapuzinerkressenkraut und Meerrettich bei akuter Sinusitis, akuter Bronchitis und akuter Blasenentzündung im Vergleich zu anderen Therapien unter den Bedingungen der täglichen Praxis.

    Arzneimittel-Forschung·2013
    Same journal

    Abstracts of the Paul-Martini-Stiftung Symposium 2012 in combination with the National Academy of Leopoldina. November 16-17, 2012. Berlin, Germany.

    Arzneimittel-Forschung·2013
    Same journal

    Leave-one-out procedure in the validation of elimination rate constant analysis.

    Arzneimittel-Forschung·2012
    Same journal

    Pharmacokinetic and myocardial enzyme profiles of two administration routes of epirubicin in breast cancer patients.

    Arzneimittel-Forschung·2012
    Same journal

    Synthesis, anti-hypertensive effect of a novel angiotensin II AT1 receptor antagonist and its anti-tumor activity in prostate cancer.

    Arzneimittel-Forschung·2012
    Same journal

    Effect of zeolite nano-materials and artichoke (Cynara scolymus L.) leaf extract on increase in urinary clearance of systematically absorbed nicotine.

    Arzneimittel-Forschung·2012
    See all related articles

    Polysorbate 80 exhibits low-order toxicity and central nervous system effects in rodents. While not suitable for isolated tissue or intravenous use, it can be safely employed as a vehicle in neuropsychopharmacological studies at specific doses.

    Area of Science:

    • Pharmacology
    • Toxicology
    • Neuroscience

    Background:

    • Polysorbate 80 (Tween 80) is a common surfactant used as a solvent in pharmacological research.
    • Understanding its toxicological profile is crucial for appropriate experimental design.

    Purpose of the Study:

    • To evaluate the toxicity and physiological effects of polysorbate 80.
    • To determine its suitability as a solvent and vehicle in various experimental settings.

    Main Methods:

    • Administration of polysorbate 80 via intraperitoneal (i.p.) and oral (p.o.) routes in mice and rats.
    • Intravenous administration in dogs.
    • Assessment of effects on isolated tissues (guinea pig ileum, rat uterus, rabbit jejunum).
    • Evaluation of cardiovascular effects on atrial preparations.

    Related Experiment Videos

  • Diuresis testing in rats.

    • Main Results:

    • Low-order toxicity observed in rodents with CNS depression, reduced locomotor activity, ataxia, and potentiation of pentobarbital sleeping time.
    • Dose-dependent hypotensive effect in dogs.
    • Antagonism of contractile responses in isolated tissues, with a direct relaxant effect on rabbit jejunum.
    • Myocardial depressant and negative inotropic effects on atrial preparations.
    • No significant diuretic effect observed.

    Conclusions:

    • Polysorbate 80 is not recommended as a solvent for isolated tissue experiments or for intravenous administration due to its observed effects.
    • It can be safely used as a vehicle in neuropsychopharmacological experiments at doses up to 1 ml/kg.