Related Experiment Video
Updated: May 10, 2025

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
Recurrent lymphocytic meningitis and progressive dementia: manifestations of relapsing polychondritis: a case report
Vanessa Ocampo-Piraquive1,2, David Aguirre-Valencia1,2, Tatiana Delgado-Mora3
1Facultad de Ciencias de la Salud, Universidad Icesi, Cl. 18 No. 122-135, Cali, Colombia.
Background:
Recurrent polychondritis is an immune-mediated systemic disease that affects cartilaginous and non-cartilaginous structures. Despite being rare, multiple neurological manifestations have been described, such as involvement of cranial nerves; headache; ataxia; seizures; confusional syndromes; meningitis; limbic encephalitis; cerebral infarcts; psychosis; and dementia. We present a case report of patient with atypical manifestation of recurrent polychondritis.
Case Presentation:
A 71-year-old man with history of three episodes of meningitis who was admitted due to headache, walking difficulties, disorientation, loss of sphincter control and prostration. These symptoms were attributed to recurrent lymphocytic meningitis and progressive dementia secondary to relapsing polychondritis with excellent response to treatment with glucocorticoids and methotrexate.
Conclusion:
The accurate identification of atypical manifestations in relapsing polychondritis is essential for the timely implementation of appropriate therapeutic interventions, thereby enhancing the overall quality of life for individuals affected by this pathology.
More Related Videos
09:35Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
07:26High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
Published on: July 18, 2017
Related Concept Videos
Parkinson's Disease: Overview
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Dementia
The progression of dementia is generally gradual....