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Supramolecular Nanoplatforms with Activable Ultrasound and Magnetic Resonance Imaging for Cancer Diagnosis and
Taoxia Liu1, Fanqi Liu1, Xindi Li1
1State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Abstract:
Excellent multifunctional platforms for cancer diagnosis and treatment are highly desirable. Herein, multifunctional nanocomposites are constructed by utilizing Mn2+ to coordinate to the imidazole moiety anchored on CuO2 nanoparticles through cyclodextrin-adamantane interaction. The encapsulated CuO2 nanoparticles (NPs) can generate hydrogen peroxide (H2O2) at tumor sites under acidic conditions upon decomposition, which is further turned into oxygen (O2) under Mn2+ catalysis, facilitating both ultrasound and magnetic resonance imaging (MRI). Moreover, the proposed nanomedicine enhances reactive oxygen species (ROS) generation and depletes glutathione (GSH), leading to increased lipid peroxidation (LPO) and effective ferroptosis-mediated cancer therapy. Such a strategy presents a promising approach for the development of theranostics for imaging-guided tumor therapy.
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