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Longitudinal changes in blood-borne geroscience biomarkers: results from a population-based study.
Anna Picca1,2, Ngoc Viet Nguyen3, Riccardo Calvani2,4
1Department of Medicine and Surgery, LUM University, Casamassima, Italy.
Geroscience
|April 24, 2025
Summary
Aging involves complex changes in metabolism and inflammation, reflected by specific blood biomarkers. This 6-year study tracked 47 markers in older adults, revealing key associations with the aging process.
Area of Science:
- Geroscience
- Biomarker Discovery
- Aging Research
Background:
- Aging is a complex process influenced by multiple biological domains.
- Understanding age-related changes requires multi-marker approaches.
- Geroscience biomarkers offer insights into aging and related conditions.
Purpose of the Study:
- Quantify geroscience biomarkers in individuals aged 60+.
- Investigate longitudinal changes in biomarker levels over 6 years.
- Describe relationships among biomarkers and their association with age and sex.
Main Methods:
- Measured 47 blood-borne biomarkers across metabolism, inflammation, vascular/organ dysfunction, cellular senescence, and neurodegeneration.
- Analyzed linear and non-linear changes in biomarkers over a 6-year follow-up.
- Assessed biomarker associations with age and sex.
Main Results:
- Found differential age-dependent changes in biomarkers across biological domains.
- Identified key metabolic (adiponectin, C-peptide, renin) and inflammatory (CXCL10, IL-1α, IL-1β, IL-6, IL-10, IL-12p70, MPO) biomarkers.
- Observed negative associations with age for IL-1α, IL-1β, IL-12p70, S100B, and Tau protein; identified non-linear age relationships for several other markers.
Conclusions:
- Inflammatory and metabolic biomarkers show strong associations with aging over 6 years.
- Specific biomarkers like IL-1α, IL-1β, and Tau protein decrease with age.
- Further multi-omics longitudinal studies are needed to explore biomarker roles in aging and health outcomes.
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