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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Related Experiment Video

Updated: May 10, 2025

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
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The cellular basis for middle-age spread.

Yong Geun Jeon1, Jae Bum Kim1

  • 1National Leader Research Initiatives Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University, Seoul, South Korea.

Science (New York, N.Y.)
|April 24, 2025
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Summary
This summary is machine-generated.

New research shows that specific fat cell precursors are responsible for the increase in visceral fat during middle age. Understanding these age-specific adipocyte progenitors is key to managing metabolic health.

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Area of Science:

  • Metabolic research
  • Cell biology
  • Aging research

Background:

  • Visceral adipose tissue (VAT) expansion is a hallmark of middle age, linked to metabolic dysfunction.
  • The cellular mechanisms driving this expansion remain incompletely understood.

Purpose of the Study:

  • To investigate the role of adipocyte progenitors in age-related VAT expansion.
  • To identify specific progenitor populations involved in middle-aged visceral fat accumulation.

Main Methods:

  • Utilized single-cell RNA sequencing to analyze cell populations in visceral adipose tissue from mice of different ages.
  • Employed lineage tracing and genetic manipulation to track and assess the function of adipocyte progenitor cells.

Main Results:

  • Identified distinct populations of adipocyte progenitors that become more active with age.
  • Demonstrated that these age-specific progenitors are the primary drivers of visceral adipose tissue expansion in middle age.
  • Showcased that inhibiting the proliferation of these progenitors can mitigate VAT expansion.

Conclusions:

  • Age-specific adipocyte progenitors are critical regulators of visceral fat accumulation during middle age.
  • Targeting these progenitors may offer a therapeutic strategy for age-related metabolic diseases.