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Related Experiment Video

Updated: May 10, 2025

Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding
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Expediting 3D printed medication development using vacuum compression moulding.

Anna Kirstine Jørgensen1, Ye Chan Oh1, Hanxiang Li1

  • 1Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|April 24, 2025
PubMed
Summary
This summary is machine-generated.

Vacuum compression moulding (VCM) enables small-scale production of accurate 3D printed medication filaments and non-destructive dose verification for personalized oral tablets. This method expedites the development of sustainable, patient-tailored medicines.

Keywords:
Chemometrics for drug quantificationExtrusion-based 3D printingFused filament fabrication additive manufacturingPharmaceutical fused deposition modelingProcess analytical technology and quality controlSustainable personalized molded printletsVacuum compression molding

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Drug Delivery Systems

Background:

  • Three-dimensional printing (3DP) offers personalized medication possibilities, but challenges exist in producing consistent drug-loaded filaments (pharma-ink) for fused-deposition modelling (FDM).
  • Non-destructive quality control for 3DP tablets requires calibration models, which can be hindered by formulation processability issues at varying drug concentrations.

Purpose of the Study:

  • To introduce vacuum compression moulding (VCM) as a novel method for small-scale pharma-ink production and non-destructive dose verification in 3DP personalized oral tablets.
  • To demonstrate the utility of VCM-produced cylindrical objects as surrogates for 3DP tablets in near-infrared (NIR) spectroscopic analysis.

Main Methods:

  • Vacuum compression moulding (VCM) was used to create dimensionally accurate pharma-ink for 3DP.
  • Tablets containing varying doses of tamoxifen were 3D printed using FDM.
  • Near-infrared (NIR) spectroscopy, calibrated using VCM samples, was employed for non-destructive dose determination in 3DP tablets.

Main Results:

  • Accurate 3D printing of tamoxifen tablets (10, 20, 30 mg) was achieved with consistent mass and drug content within pharmacopoeial limits.
  • Drug release profiles were consistent across different tablet sizes.
  • The NIR model, calibrated with VCM surrogates, accurately predicted tamoxifen dose in 3DP tablets, showing excellent linearity (R² = 0.997) and robustness (R²cv = 0.996).

Conclusions:

  • VCM is a viable method for producing accurate pharma-ink and serves as an effective surrogate for developing non-destructive NIR quality control methods in 3DP.
  • Synergistic use of VCM and FDM printing accelerates the development of personalized oral medicines with improved material sustainability.