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Post-stroke Arrhythmias: Performance of Brain-heart Crosstalk Networks
Longxiao Liu1,2, Bangqi Wu2, Jingjie Huang1,2
1Tianjin University of Traditional Chinese Medicine, 88 Changling Road, Tianjin 301617, China.
Insights
Stroke can trigger new heart arrhythmias, distinct from primary conditions. Understanding brain-heart crosstalk mechanisms may reveal novel therapeutic targets for post-stroke cardiac events.
Area of Science:
- Neurology
- Cardiology
- Pathophysiology
Background:
- Stroke and heart disease are leading global health burdens with a potential causal link.
- Arrhythmias are often studied in relation to stroke, but cardiac issues frequently arise post-stroke.
Purpose of the Study:
- To review brain-heart crosstalk mechanisms following stroke.
- To explore the concept of post-stroke arrhythmia as a distinct stroke-induced condition.
- To identify new therapeutic targets for managing post-stroke cardiac complications.
Main Methods:
- Review of current literature on brain-heart interactions after stroke.
- Examination of potential mechanisms including autonomic imbalance, gut microbiota, and inflammation.
- Analysis of the impact of arrhythmia on stroke severity and brain injury localization.
Main Results:
- Clinical evidence indicates increased arrhythmia incidence post-stroke, even without prior history.
- Cardiac disease is a significant cause of mortality after stroke.
- Proposed mechanisms of brain-heart crosstalk include catecholamine surge, dysbiosis, and inflammation.
Conclusions:
- Post-stroke arrhythmia may represent a unique stroke-induced pathology.
- Understanding these brain-heart interactions is crucial for developing targeted treatments.
- New pharmacological and non-pharmacological strategies are needed for clinical guidance.
Abstract:
Stroke and heart disease are two of the leading causes of the global disease burden. However, modern research has gradually revealed a potential causal link between these two conditions. Most studies have focused on the direct role of arrhythmias in stroke. However, clinical evidence suggests that the incidence of arrhythmias increases after stroke in patients without a history of arrhythmia, and cardiac disease after stroke has become the second leading cause of death after stroke. This article focuses on arrhythmias after stroke and reviews brain-heart crosstalk after stroke. This article examines the potential mechanisms of brain-heart interactions after stroke, including increased catecholamines due to autonomic imbalance, gut microbial dysbiosis, immune response, and systemic inflammation. In addition, this article discusses the impact of arrhythmia on stroke severity and the role of brain injury sites in brain-heart interactions. To address these mechanisms, we propose that post-stroke arrhythmia is a type of stroke-induced disease distinct from primary arrhythmia. We aimed to identify new therapeutic targets and treatments, both pharmacological and non-pharmacological, to achieve targeted treatment and provide guidance for future clinical prevention and treatment.
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