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Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
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Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
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Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm
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Exploring Factors Affecting Psychological Flexibility After Psychedelic Experiences.

B Romeo1,2, E Kervadec1, B Fauvel3

  • 1Department of Psychiatry and Addictology, APHP, Paul Brousse Hospital, Villejuif, France.

Journal of Psychoactive Drugs
|April 25, 2025
PubMed
Summary
This summary is machine-generated.

Psychedelic use can enhance psychological flexibility, particularly after intense mystical experiences. These changes are linked to baseline flexibility and frequency of use, suggesting therapeutic potential.

Keywords:
LSDPsychedelicacceptance and commitment therapypsilocybinpsychological flexibility

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Area of Science:

  • Psychopharmacology
  • Clinical Psychology

Background:

  • Psychedelics are hypothesized to enhance psychological flexibility by disrupting rigid cognitive patterns.
  • This transdiagnostic potential suggests therapeutic applications across various mental health conditions.

Purpose of the Study:

  • To identify the key factors influencing changes in psychological flexibility after psychedelic experiences.
  • To explore the relationship between mystical experience intensity and psychological flexibility.

Main Methods:

  • A retrospective online survey of French individuals reporting significant psychedelic experiences.
  • Assessment of mystical experience intensity (MEQ-30) and psychological flexibility (AAQ-II) at multiple time points.
  • Statistical analyses including correlation, ANCOVA, and linear regression to determine predictors of change.

Main Results:

  • A significant positive correlation was found between mystical experience intensity and improvements in psychological flexibility.
  • Improvements were noted 1 month post-experience and persisted for up to 6 months.
  • Baseline psychological flexibility, mystical experience intensity (MEQ-30), and frequent psychedelic use predicted changes.

Conclusions:

  • The intensity of the mystical experience is a crucial factor in post-psychedelic psychological flexibility enhancement.
  • Individual baseline psychological flexibility levels interact with psychedelic experiences to influence therapeutic outcomes.
  • Findings suggest that psychedelics, particularly when associated with profound experiences, may hold therapeutic value for improving psychological flexibility.