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Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
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Related Experiment Video

Updated: May 20, 2025

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
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Upconversion-Based Photodynamic Therapy for Psoriatic Dermatitis.

Zhenjia Lin1, Xiaoyu Ji2, Jinyu Liu1

  • 1Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China.

ACS Applied Bio Materials
|April 25, 2025
PubMed
Summary
This summary is machine-generated.

Upconversion nanoparticles (UCNPs) offer a novel approach to photodynamic therapy (PDT) for psoriasis. This study shows UCNPs-mediated PDT effectively treats psoriatic dermatitis by targeting macrophages and suppressing skin cell overproliferation.

Keywords:
macrophagephotodynamic therapypsoriasisreactive oxygen speciesupconversion

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Dermatology

Background:

  • Psoriasis affects 2-3% globally, causing erythema, scales, and comorbidities, significantly impacting quality of life.
  • Current psoriasis treatments like biologics, traditional drugs, and phototherapy have limitations including cost, efficacy, and side effects.
  • Photodynamic therapy (PDT) shows promise but is limited by poor light penetration for photosensitizers.

Purpose of the Study:

  • To develop and evaluate upconversion nanoparticles (UCNCNPs) for enhanced photodynamic therapy (PDT) in psoriasis treatment.
  • To overcome the challenge of limited light penetration in traditional PDT for psoriasis.
  • To investigate the efficacy of UCNPs-mediated PDT using near-infrared (NIR) light for psoriatic dermatitis.

Main Methods:

  • Synthesized UCNPs coated with a porous silica shell and encapsulated with a photosensitizer (ZnPc) to form UCNPs-ZnPc.
  • Topically applied UCNPs-ZnPc to psoriatic mouse models.
  • Activated UCNPs-ZnPc with 980 nm NIR light to induce reactive oxygen species generation.

Main Results:

  • UCNPs-ZnPc were effectively taken up by macrophages in psoriatic mouse skin.
  • NIR light activation of UCNPs-ZnPc led to reduced macrophage viability.
  • Treatment suppressed the overproliferation of psoriatic skin cells, effectively treating dermatitis.
  • Demonstrated successful application of UCNPs-mediated PDT in a preclinical psoriasis model.

Conclusions:

  • UCNPs-mediated PDT offers a promising strategy to overcome light penetration limitations in psoriasis treatment.
  • This approach effectively targets macrophages and inhibits psoriatic skin cell proliferation.
  • UCNPs-ZnPc represents an innovative therapeutic avenue for managing psoriasis with potential for improved clinical outcomes.