Related Experiment Video
Updated: May 17, 2025
08:51
Applying an Inducible Expression System to Study Interference of Bacterial Virulence Factors with Intracellular Signaling
Published on: June 25, 2015
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Robust Inducible Gene Expression in Intracellular Listeria monocytogenes In Vivo
Huong Giang Pham1, Kiet N Tran1, Larissa Gomelsky1
1Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, United States.
ACS Synthetic Biology
|April 25, 2025
Summary
Engineered bacteria deliver cancer payloads. A new system uses a cumin derivative to control gene expression in bacteria within tumors, enhancing safety and efficacy for cancer therapy.
Area of Science:
- Microbiology
- Biotechnology
- Oncology
Background:
- Attenuated Listeria monocytogenes are promising for delivering payloads to tumor cells.
- Tumor microenvironments are preferential sites for L. monocytogenes accumulation.
- Controlling payload synthesis timing is crucial for maximizing tumor impact and minimizing healthy tissue damage.
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