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Supervised Physical Activity Interventions in Children and Adolescents with Cancer Undergoing Treatment-A Systematic
Nadja Battanta1, Krystyna Lange1, Sabine V Kesting2,3
1Division of Oncology/Hematology, Children's Hospital of Eastern Switzerland, 9006 St. Gallen, Switzerland.
Current Oncology (Toronto, Ont.)
|April 25, 2025
Summary
Physical activity (PA) interventions are safe and feasible for children and adolescents undergoing cancer treatment. While showing promise for improving fitness and quality of life, more research is needed to confirm long-term benefits.
Area of Science:
- Pediatric Oncology
- Exercise Science
- Rehabilitation Medicine
Background:
- Cancer treatment significantly reduces physical activity in children and adolescents.
- This decline impacts their development and overall health.
- A comprehensive review on physical activity interventions in this population is lacking.
Purpose of the Study:
- To systematically review the safety, feasibility, clinical effectiveness, and long-term impact of physical activity interventions.
- To evaluate interventions for pediatric and adolescent cancer patients up to 25 years of age.
Main Methods:
- Systematic literature review following PRISMA guidelines.
- Included studies on physical activity interventions during cancer treatment.
- Assessed risk of bias using Joanna Briggs Institute tools.
- Used descriptive analysis due to heterogeneity.
Main Results:
- 21 studies were included, with 10 being randomized controlled trials.
- Physical activity interventions were safe and feasible when individualized.
- Improvements observed in physical fitness, strength, quality of life, and reduced fatigue.
- Heterogeneity and small sample sizes limited definitive conclusions.
Conclusions:
- Physical activity is a safe and feasible adjunct to cancer treatment for pediatric and adolescent patients.
- Promising trends suggest benefits, but further large-scale, multicenter trials are necessary.
- Standardized protocols are needed to establish long-term benefits and optimal interventions.
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