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The Gut Mycobiome for Precision Medicine
Islam El Jaddaoui1,2,3, Sofia Sehli3, Najib Al Idrissi3
1Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, University Mohammed V, Rabat 10000, Morocco.
Journal of Fungi (Basel, Switzerland)
|April 25, 2025
Summary
The gut mycobiome, though small, significantly impacts health and disease. Research is exploring its role in precision medicine for diagnostics and therapeutics, despite clinical translation challenges.
Area of Science:
- Microbiology
- Human Health
- Medical Research
Background:
- The human gastrointestinal tract hosts a complex microbiome, with bacteria being dominant.
- Fungi, a smaller component of the gut microbiome, are increasingly recognized for their significant health and disease implications.
- Advances in multi-omics and computational biology enable deeper study of the gut mycobiome.
Purpose of the Study:
- To review the gut fungal microbiota.
- To highlight analytical methods for studying the mycobiome.
- To discuss the mycobiome's association with human diseases and its potential in precision medicine.
Main Methods:
- Next-generation sequencing
- Metagenomics
- Metatranscriptomics
- Metaproteomics
- Metabolomics
- Computational biology
Main Results:
- Emerging evidence links fungal dysbiosis to inflammatory bowel disease, colorectal cancer, metabolic disorders, and neurological conditions.
- The gut mycobiome shows potential for biomarker discovery, disease diagnostics, and targeted therapeutics in precision medicine.
Conclusions:
- The gut mycobiome plays a crucial role in human health and disease.
- Further research and overcoming clinical translation barriers are needed to integrate mycobiome knowledge into practice for diagnosis and treatment.
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