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Updated: May 10, 2025

Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
Impact of Removing Race Coefficient from Glomerular Filtration Rate Estimation Equations on Antidiabetics Among Black
Dhakrit Rungkitwattanakul1, Ebony Evans1, Ewanna Brown2
1Department of Clinical and Administrative Pharmacy Science, Howard University College of Pharmacy, Washington, DC 20059, USA.
Background:
In 2021, the National Kidney Foundation-American Society of Nephrology (NKF-ASN) recommended the use of the 2021 refit equation without race; however, the effect of the removal is unclear. Our research aimed to examine the implications of antidiabetic dosing and eligibility on the new 2021 equation among Black patients.
Methods:
This is a retrospective analysis of patients receiving care at the diabetes treatment center (DTC) of an academic medical center. Estimated glomerular filtration rates (eGFRs) based on serum creatinine were calculated using the 2009 and 2021 CKD-EPI equations. A Monte Carlo simulation was performed to create 10,000 virtual patients. Dosing simulations based on each estimate of kidney function were performed for antidiabetics based on product labeling. The proportion and percentage of patients who were eligible based on the estimates were calculated.
Results:
The percentages of patients ineligible for metformin based on the estimates from the 2009 and 2021 CKD-EPI equations at the DTC were comparable (8.02% and 8.36%, respectively). In our 10,000 simulated virtual patients, the percentage of ineligibility increased only by 1%. For the GFR cut points of 20 mL/min and 25 mL/min, the rates of ineligibility were similar in our cohort and simulated patients.
Conclusions:
The exclusion of race from the 2021 CKD-EPI equation may slightly reduce medication eligibility among Black patients.
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