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Humanized Mouse Systems to Study Viral Infection: A New Era in Immunology Research
Angela Wahl1, J Victor Garcia1
1Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA ; email: awahl@uab.edu, jvgarcia@uab.edu.
Annual Review of Immunology
|April 25, 2025
Summary
Humanized mouse models offer a more accurate way to study viral infections and immune responses compared to traditional animal models. These advanced systems are crucial for understanding human-specific viruses and developing new therapies.
Area of Science:
- Immunology
- Virology
- Infectious Diseases
Background:
- Traditional animal models have limitations in studying human viral infections.
- The human-pathogen interface requires more accurate research models.
- Humanized mouse systems have emerged as a significant advancement.
Purpose of the Study:
- To explore the history, development, and advantages of humanized mouse systems.
- To detail the utility of these models in viral immunology research.
- To emphasize their application in studying human-specific viruses.
Main Methods:
- Review of existing literature on humanized mouse model development.
- Description of different types of humanized mouse models.
- Analysis of their generation and application in viral research.
Main Results:
- Humanized mouse models provide a superior platform for studying viral infections.
- These models enhance understanding of human immune responses to viruses.
- They offer insights into disease control and exacerbation mechanisms.
Conclusions:
- Humanized mouse systems are revolutionizing viral immunology research.
- They are vital for developing novel treatments and therapies for viral diseases.
- Further refinement and application of these models hold significant future potential.
