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Updated: Jun 16, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Results from a multiple sclerosis relapse clinic
Ger Mullan1, Rachael Kee1, Fiona Kennedy2
1Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, United Kingdom; Department of Neurology, Belfast Health and Social Care Trust, United Kingdom.
Background:
A multiple sclerosis (MS) relapse clinic can lead to early diagnosis and management of MS relapses, yet published outcomes from MS relapse clinics are scarce.
Methods:
We analysed the Belfast Health and Social Care Trust (BHSCT) relapse clinic over a 12 month period.
Results:
Only 16 % of attendees were diagnosed with a relapse, defined as new neurological symptoms with radiological evidence of new disease activity. Pseudorelapse was a more common cause of presentation (19 %) than relapse. Corticosteroid therapy was administered in 3 % of all attendances.
Conclusions:
This low figure highlights the importance of clinical evaluation of new symptoms, justifies caution in corticosteroid prescribing and may reflect the impact of highly-effective therapies. We encourage other groups to publish their relapse clinic findings to best characterise the frequency of relapses and the utility of such services using real world data.
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