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Updated: Jun 16, 2025

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Neuron-astrocyte coupling in lateral habenula mediates depressive-like behaviors

Qianqian Xin1, Junying Wang1, Jinkun Zheng2

  • 1Department of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Nanhu Brain-Computer Interface Institute, Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, State Key Laboratory of Brain-Machine Intelligence, New Cornerstone Science Laboratory, Zhejiang University, Hangzhou 311121, China.

Cell
|April 25, 2025
PubMed
Summary

Stress rapidly activates astrocytes in the lateral habenula (LHb), initiating a feedback loop that influences depression. This neuron-glia interaction highlights astrocytes as key signaling relays in stress response and depression.

Keywords:
SNRIastrocytesdepressionlateral habenulalocus coeruleusnorepinephrinephasic and tonic NEreboxetinestressα(1A)-adrenergic receptor

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